Megalin-Mediated Oligonucleotide Trafficking for Breast Cancer Chemosensitization PRINCIPAL INVESTIGATOR:

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression

Receptors internalized by endocytosis can return to the plasma membrane (PM) directly from early endosomes (EE; fast recycling) or they can traffic from EE to the endocytic recycling compartment (ERC) and recycle from there (slow recycling). How receptors are sorted for trafficking along these two pathways remains unclear. Here we show that autosomal recessive hypercholesterolemia (ARH) is requ...

GRANT NUMBER DAMD17-94-J-4213 TITLE: Role of Parathyroid Hormone-Related Protein in Breast Cancer Mediated Osteolysis PRINCIPAL INVESTIGATOR:

The Role of MEKK3 Signaling Pathway in the Resistance of Breast Cancer Cells to TNF-Alpha-Mediated Apoptosis PRINCIPAL INVESTIGATOR:

Ling Yu, Huang Q., Kim K., Wang X. and Su, B. Role of MEKK3 signaling in the resistance of breast cancer cells to TNFa-mediated apoptosis. Breast Cancer Research Program meeting, DOD, Philadelphia, PA. June 6-12, 2005. Presentation: Poster presentation: Ling Yu, Juang,Q., Kim K., Wang X. and Su, B. Role of MEKK3 signaling in the resistance of breast cancer cells to TNFa-mediated apoptosis. Brea...

Progenitor Cell Fate Decisions in Mammary Tumorigenesis

Crowe DL, Wan R, Baloue K. 2011. Coordinate activation of the NBS1 gene regulates estradiol mediated protection from double strand DNA breaks. Era of Hope Breast Cancer Research Meeting. Orlando, FL Published manuscripts: Wan R, Crowe DL. 2012. Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis. Int J Oncol 41:345-352 Wan R, Wu J, Baloue K...

AD AWARD NUMBER DAMD17-97-1-7144 TITLE: Tomosynthesis Breast Imaging: Early Detection and Characterization of Breast Cancer PRINCIPAL INVESTIGATOR:

AWARD NUMBER DAMD17-97-1-7144 TITLE: Tomosynthesis Breast Imaging: Early Detection and Characterization of Breast Cancer PRINCIPAL INVESTIGATOR: Loren T. Niklason, Ph.D. CONTRACTING ORGANIZATION: Massachusetts General Hospital Boston, Massachusetts 02114 REPORT DATE: July 1998 ^\$> TYPE OF REPORT: Annual "P^ PREPARED FOR: Commander U.S. Army Medical Research and Materiel Command Fort Detrick, M...